|Year : 2018 | Volume
| Issue : 2 | Page : 47
Current practices and research in regenerative endodontics: A brief summary
Thomas Anthony Montagnese
Associate Professor, Department of Endodontics, School of Dental Medicine, Case Western Reserve University, Cleveland, Ohio, USA
|Date of Web Publication||3-Aug-2018|
Dr. Thomas Anthony Montagnese
1550 Cooper Foster Park Road West, Lorain, Ohio 44053
Source of Support: None, Conflict of Interest: None
|How to cite this article:|
Montagnese TA. Current practices and research in regenerative endodontics: A brief summary. Int J Growth Factors Stem Cells Dent 2018;1:47
Regenerative techniques are not new to endodontics. Procedures such as direct pulp capping, apexogenesis, and apexification use bioactive materials to stimulate growth factors to form hard tissue barriers or to allow for continued growth of pulp tissue. These procedures have been done in the past without the intentional activation of growth factors to induce stem cells to form specific types of tissue.
At present, work is being done to “re-vascularize” the root canal system of immature teeth with necrotic pulps. The intention is to stimulate the formation of dentin and to allow the complete development of the root. The three main elements are stem cells, scaffolds, and growth factors.
The main difficulty to overcome in re-vascularization attempts is disinfection of the infected root canal system. Initially, a triple antibiotic paste consisting of minocycline, metronidazole, and ciprofloxacin has been used to disinfect the root canal system, and work is being done using a double antibiotic paste. This is to eliminate the staining caused by minocycline. The search continues to find and develop ways to accomplish this without destroying stem cells and growth factors.
The ultimate goal in re-vascularization is to stimulate the formation of normal pulp tissue which in turn will allow the normal development and function of the tooth.
The American Association of Endodontists in the publication of Colleagues for Excellence (Spring 2013) provides an excellent summary on the topic.
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