• Users Online: 424
  • Print this page
  • Email this page
Year : 2018  |  Volume : 1  |  Issue : 2  |  Page : 74-77

Application of liquid platelet-rich fibrin for treating hyaluronic acid-related complications: A case report with 2 years of follow-up

1 Department of Oral, Cranio-Maxillofacial and Facial Plastic Surgery, Goethe University Frankfurt, Frankfurt, Germany
2 Pain Therapy Center, Nice, France
3 Dental Aesthetic Clinic, Athens, Greece

Correspondence Address:
Prof. Shahram Ghanaati
Department for Oral, Cranio-Maxillofacial and Facial Plastic Surgery, Goethe University Frankfurt, Form-Lab, Theodor-Stern-Kai 7, D-60590 Frankfurt
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/GFSC.GFSC_11_18

Rights and Permissions

Platelet-rich fibrin (PRF) is a blood concentrate system derived from the peripheral blood by means of centrifugation. In esthetic medicine, hyaluronic acid (HA) is safe and most frequently used for esthetic treatment and skin augmentation. However, some complications such as inflammation were reported in the literature after the injection of HA as a xenogeneic material. The present case report presents a case of the treatment of complication after HA injection. The subject received the injection of HA in combination with filler material and developed a purulent and granulomatous dermal and subdermal skin infection that was eliminated by incision. To prevent scar formation, the subject was treated with dermal and subdermal liquid PRF injections for 1 year, and the case was documented for 2 years. The PRF injections promoted wound healing and minimized the scar formation. After two sessions, the patient swelling and redness were significantly decreased compared to baseline. After 4 sessions, complete wound healing was achieved without obvious scar formation. This case report shows that the use of liquid PRF as a bioactive system promotes wound healing and skin regeneration as well as minimizes scar formation. However, controlled clinical studies are needed to further elucidate the benefit of PRF as an autologous and bioactive material for esthetic skin treatment.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded948    
    Comments [Add]    
    Cited by others 7    

Recommend this journal