• Users Online: 384
  • Print this page
  • Email this page

Table of Contents
Year : 2020  |  Volume : 3  |  Issue : 1  |  Page : 1-2

New and improved platelet-rich fibrin membranes

1 Department of Oral Surgery, Dentistry School, Fluminense Federal University, Niterói, Rio de Janeiro, Brazil; South Bay Dental Institute, Los Angeles, California, USA, USA
2 South Bay Dental Institute, Los Angeles, California, USA

Date of Submission07-Apr-2020
Date of Acceptance08-Apr-2020
Date of Web Publication16-Apr-2020

Correspondence Address:
Prof. Carlos Fernando de Almeida Barros Mourao
1622 S Gaffey Street, San Pedro, CA 90731
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/GFSC.GFSC_5_20

Rights and Permissions

How to cite this article:
Mourao CF, Javid K. New and improved platelet-rich fibrin membranes. Int J Growth Factors Stem Cells Dent 2020;3:1-2

How to cite this URL:
Mourao CF, Javid K. New and improved platelet-rich fibrin membranes. Int J Growth Factors Stem Cells Dent [serial online] 2020 [cited 2024 Mar 2];3:1-2. Available from: https://www.cellsindentistry.org/text.asp?2020/3/1/1/282569

After the publication of Alb-CGF (Albumin + Concentrated Growth Factors) in our journal,[1] other studies began to be developed, for example, evaluation of biocompatibility and demonstrating a new biological characterization.[2] In this latest article, we started to adopt the name Alb-PRF (Albumin + Platelet rich fibrin (PRF)).

Alb-PRF is a blood by-product, without additives, using only autologous blood, which after centrifugation will be produced in two stages: heating and incorporation: heating of serum and platelet-poor plasma and incorporation of cells (GFs and cytokines of the liquid PRF, removed from junction of the buffy coat area and the red blood cells).[1],[2]

This novel biomaterial was already tested in vitro, and the translational research with this new material has already been started. It is possible to expect excellent results for the use of Alb-PRF, not only for oral surgery/periodontal applications, but also for use in medicine and facial esthetics.[3]

Earlier this year, we started procedures to improve the quality and the adaptations of the Alb-PRF. One of the weaknesses of the membrane produced from this process is elasticity. Alb-PRF is not a product that accepts tension during the suturing process in surgical procedures, and its flexibility is very different from that presented by the standard PRF membrane.

Thinking about Alb-PRF fragility, the laser pulse-PRF (LP-PRF) was produced.

LP-PRF is the optimized phase of Alb-PRF for use in surgical procedures, allowing the suture/fixation of the membrane, with increased stability in the body, as well as with the use of Alb-PRF, however, without presenting the fragility of the Alb-PRF membrane.

The LP-PRF production process is simple when high-power laser equipment is present [Figure 1]. Only one layer of the PRF membrane is heated by the apparatus [Figure 2], allowing the inverse part to remain with the macrostructure and elasticity similar to the standard PRF membrane [Figure 3].
Figure 1: The use of high-potency laser to heat the platelet-rich fibrin membrane

Click here to view
Figure 2: Platelet-rich fibrin after laser pulse

Click here to view
Figure 3: The other side of laser pulse-platelet-rich fibrin membrane showing the same macrostructure of the simple platelet-rich fibrin membrane

Click here to view

For those who do not have equipment such as a laser, the heat-PRF is in the process of development, where it will be possible, with more straightforward equipment, to have controlled heating on only one side of the PRF membrane. It will allow maintaining elasticity and viable cells (GFs and cytokines), producing a membrane/barrier for guided bone regeneration and periodontal procedures, among other applications in the dental and medical fields.

  References Top

Barros Mourão CF, Gheno E, Lourenço ES, Barbosa RD, Kurtzman GM, Javid K, et al. Characterization of a new membrane from concentrated growth factors associated with denaturized albumin (Alb-CGF) for clinical applications: A preliminary study. Int J Growth Factors Stem Cells Dent 2018;1:64-9.  Back to cited text no. 1
Fujioka-Kobayashi M, Schaller B, Mourão CF, Zhang Y, Sculean A, Miron RJ. Biological characterization of an injectable platelet-rich fibrin mixture consisting of autologous albumin gel and liquid platelet-rich fibrin (Alb-PRF). Platelets 2020:1-8.  Back to cited text no. 2
Mourão CFAB, Tuttle D, Carpini R, Delboccio S, Miron R, Davies C. Future trends in esthetic medicine. In: Davies C, Miron RJ, editors. PRF in Facial Esthetics. Chicago, USA: Quintessence; 2020.  Back to cited text no. 3


  [Figure 1], [Figure 2], [Figure 3]

This article has been cited by
1 Innovative Concepts and Recent Breakthrough for Engineered Graft and Constructs for Bone Regeneration: A Literature Systematic Review
Francesco Inchingolo, Denisa Hazballa, Alessio Danilo Inchingolo, Giuseppina Malcangi, Grazia Marinelli, Antonio Mancini, Maria Elena Maggiore, Ioana Roxana Bordea, Antonio Scarano, Marco Farronato, Gianluca Martino Tartaglia, Felice Lorusso, Angelo Michele Inchingolo, Gianna Dipalma
Materials. 2022; 15(3): 1120
[Pubmed] | [DOI]
2 The Platelet Concentrates Therapy: From the Biased Past to the Anticipated Future
Tomoyuki Kawase,Suliman Mubarak,Carlos Fernando Mourão
Bioengineering. 2020; 7(3): 82
[Pubmed] | [DOI]


    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
    Access Statistics
    Email Alert *
    Add to My List *
* Registration required (free)  

  In this article
Article Figures

 Article Access Statistics
    PDF Downloaded1163    
    Comments [Add]    
    Cited by others 2    

Recommend this journal