International Journal of Growth Factors and Stem Cells in Dentistry

: 2020  |  Volume : 3  |  Issue : 1  |  Page : 1--2

New and improved platelet-rich fibrin membranes

Carlos Fernando de Almeida Barros Mourao1, Kayvon Javid2,  
1 Department of Oral Surgery, Dentistry School, Fluminense Federal University, Niterói, Rio de Janeiro, Brazil; South Bay Dental Institute, Los Angeles, California, USA, USA
2 South Bay Dental Institute, Los Angeles, California, USA

Correspondence Address:
Prof. Carlos Fernando de Almeida Barros Mourao
1622 S Gaffey Street, San Pedro, CA 90731

How to cite this article:
Mourao CF, Javid K. New and improved platelet-rich fibrin membranes.Int J Growth Factors Stem Cells Dent 2020;3:1-2

How to cite this URL:
Mourao CF, Javid K. New and improved platelet-rich fibrin membranes. Int J Growth Factors Stem Cells Dent [serial online] 2020 [cited 2023 Dec 1 ];3:1-2
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Full Text

After the publication of Alb-CGF (Albumin + Concentrated Growth Factors) in our journal,[1] other studies began to be developed, for example, evaluation of biocompatibility and demonstrating a new biological characterization.[2] In this latest article, we started to adopt the name Alb-PRF (Albumin + Platelet rich fibrin (PRF)).

Alb-PRF is a blood by-product, without additives, using only autologous blood, which after centrifugation will be produced in two stages: heating and incorporation: heating of serum and platelet-poor plasma and incorporation of cells (GFs and cytokines of the liquid PRF, removed from junction of the buffy coat area and the red blood cells).[1],[2]

This novel biomaterial was already tested in vitro, and the translational research with this new material has already been started. It is possible to expect excellent results for the use of Alb-PRF, not only for oral surgery/periodontal applications, but also for use in medicine and facial esthetics.[3]

Earlier this year, we started procedures to improve the quality and the adaptations of the Alb-PRF. One of the weaknesses of the membrane produced from this process is elasticity. Alb-PRF is not a product that accepts tension during the suturing process in surgical procedures, and its flexibility is very different from that presented by the standard PRF membrane.

Thinking about Alb-PRF fragility, the laser pulse-PRF (LP-PRF) was produced.

LP-PRF is the optimized phase of Alb-PRF for use in surgical procedures, allowing the suture/fixation of the membrane, with increased stability in the body, as well as with the use of Alb-PRF, however, without presenting the fragility of the Alb-PRF membrane.

The LP-PRF production process is simple when high-power laser equipment is present [Figure 1]. Only one layer of the PRF membrane is heated by the apparatus [Figure 2], allowing the inverse part to remain with the macrostructure and elasticity similar to the standard PRF membrane [Figure 3].{Figure 1}{Figure 2}{Figure 3}

For those who do not have equipment such as a laser, the heat-PRF is in the process of development, where it will be possible, with more straightforward equipment, to have controlled heating on only one side of the PRF membrane. It will allow maintaining elasticity and viable cells (GFs and cytokines), producing a membrane/barrier for guided bone regeneration and periodontal procedures, among other applications in the dental and medical fields.


1Barros Mourão CF, Gheno E, Lourenço ES, Barbosa RD, Kurtzman GM, Javid K, et al. Characterization of a new membrane from concentrated growth factors associated with denaturized albumin (Alb-CGF) for clinical applications: A preliminary study. Int J Growth Factors Stem Cells Dent 2018;1:64-9.
2Fujioka-Kobayashi M, Schaller B, Mourão CF, Zhang Y, Sculean A, Miron RJ. Biological characterization of an injectable platelet-rich fibrin mixture consisting of autologous albumin gel and liquid platelet-rich fibrin (Alb-PRF). Platelets 2020:1-8.
3Mourão CFAB, Tuttle D, Carpini R, Delboccio S, Miron R, Davies C. Future trends in esthetic medicine. In: Davies C, Miron RJ, editors. PRF in Facial Esthetics. Chicago, USA: Quintessence; 2020.